Publications
Erb-Zohar K, Sourgens H, Breithaupt-Groegler K, Klipping C (2021):
Unintended drug exposure during pregnancy in clinical trials - a survey in early drug development.
Int J Clin Pharmacol Ther. 2021 Jan;59(1):26-30.
Rengelshausen J, Breithaupt-Groegler K, Donath F, Erb-Zohar K, Hardman T, Mikus G, Plassmann S, Wensing G, Sourgens H (2021):
How to Interpret an Investigator's Brochure for Meaningful Risk Assessment: Results of an AGAH Discussion Forum.
Ther Innov Regul Sci. 2021 Feb 3:1-7. doi: 10.1007/s43441-021-00257-0.
Hardman T, Caplain H, Rottey S, Douglas D, Stringer S and Sourgens H (2019):
European Federation for Exploratory Medicines Development Lyon Conference 2019: The Changing Landscape of Early Medicines Development—Be Prepared.
Front. Pharmacol. 10:1377. doi: 10.3389/fphar.2019.01377.
Breithaupt-Groegler K, Hardman T, de Hoon J, Donazzolo Y, Rottey S, Sourgens H, Stringer S:
The New First-in-Human EMA Guideline: Disruptive or Constructive? Outcomes From the First EUFEMED Discussion Forum.
Front Pharmacol. 2019 Apr 24;10:398. doi: 10.3389/fphar.2019.00398. eCollection 2019.
Erb-Zohar K, Sourgens H, Breithaupt-Groegler K:
Use of integrated clinical trial protocols - a survey in early medicines development.
Int J Clin Pharmacol Ther. 2018 Feb 16. doi: 10.5414/CP203206. [Epub ahead of print] PubMed PMID: 29451470.
Van Bortel L, Sourgens H, Breithaupt-Grögler K, Caplain H, Donazzolo Y, Klingmann I, Hammond M, Hardman TC, Stringer S, de Hoon J:
EUFEMED London Conference 2017: Exploratory Medicines Development: Innovation and Risk Management.
Front Pharmacol. 2018 Jan 17;8:901. doi: 10.3389/fphar.2017.00901. eCollection 2017. PubMed PMID: 29387006; PubMed Central PMCID: PMC5776107.
Breithaupt-Groegler K, Coch C, Coenen M, Donath F, Erb-Zohar K, Francke K, Goehler K, Iovino M, Kammerer Kp, Mikus G, Rengelshausen J, Sourgens H, Schinzel R, Sudhop T, Wensing G:
Who is a 'healthy subject'? - consensus results on pivotal eligibility criteria for clinical trials.
Eur J Clin Pharmacol. 2017 Jan 7. doi: 10.1007/s00228-016-2189-8.
Sourgens H, Lefrère F:
A systematic review of available clinical evidence - filgrastim compared with lenograstim.
International Journal of Clinical Pharmacology and Therapeutics 2011; 49: 510-518
Sourgens H., M.A. Bertola, J.S.C. Verschoor, M. Kuipers and B. Rayer:
Amoxicillin/clavulanic acid (875/125): bioequivalence of a novel Solutab (R) tablet and rationale for a
twice-daily dosing regimen.
International Journal of Clinical Pharmacology and Therapeutics, Vol. 42, No. 2, 165-173, 2004
Sourgens H, J. Schmidt, H. Derendorf:
Comparison of talinolol and atenolol effects on blood pressure in relation to lipid and glucose
metabolic parameters. Results from the TALIP study.
Int J Clin Pharmacol Ther. 41, 22-9, 2003
Michael N., H. Sourgens, V. Arolt, A. Erfurth:
Severe tardive dyskinesia in affective disorders: treatment with vitamin E and C.
Neuropsychobiology 46, Suppl 1, 28-30, 2002
Sourgens H., H. Steinbrede, Js. Verschoor, Ma. Bertola, B. Rayer:
Bioequivalence study of a novel Solutab tablet formulation of amoxicillin/clavulanic acid versus the
originator film-coated tablet.
Int J Clin Pharmacol Ther. 39, 75-82, 2001
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?
cmd=Retrieve&db=PubMed&list_uids=11270805&
dopt=Citation
Sourgens H.:
Drug Interactions: Gefährdung der Substitution
in: Christian Jellinek / Bernd Westermann / Gabriele U. Bellmann (Hrsg.) Beigebrauch Offene
Grenzen der Substitution BELTZ Deutscher Studien Verlag Weinheim 2000
Sourgens H., R. Hoerr, A. Biber, H. Steinbrede, and H. Derendorf:
KA 672-HCl, a neuronal activator against dementia: tolerability, safety, and preliminary
pharmacokinetics after single and multiple oral doses in healthy male and female volunteers.
J Clin Pharmacol 38, 373-381, 1998
Sourgens H., H. Derendorf, H. Schifferer:
Pharmacokinetic profile of cefaclor.
Int. J. Clin. Pharmacol. Ther. 35, 374-380, 1997
Merfort F., H. Von Ahlen, Th. Zimmermann, H. Sourgens:
Neue Aspekte in Diagnostik und Therapie der erektilen Dysfunktion.
Münchener Medizinische Wochenschrift 138, 28/504, 1996
Rohatagi S., G. Hochhaus, H. Möllmann, J. Barth, E. Galia, M. Erdmann, H. Sourgens, and H. Derendorf:
Pharmacokinetic and pharmacodynamic evaluation of triamcinolone acetonide after intravenous, oral,
and inhaled administration.
J Clin Pharmacol 35, 1187-1193, 1995
Derendorf, H., G. Hochhaus, S. Rohatagi, H. Möllmann, J. Barth, H. Sourgens, H. Erdmann:
Pharmacokinetics of triamcinolone acetonide after intravenous, oral and inhaled administration.
J. Clin. Pharmacol. 35, 302-305, 1995
Barth A., N. Kaiser, U. Loffler, H. Sourgens, and W. Klinger:
Influence of the xanthine derivative denbufylline and the antiinflammatory agent nabumetone on
microsomal free-radical production and lipid peroxidation in rat liver.
Experimental and Toxicologic Pathology 46, 483-489, 1994
Sourgens, H.:
Überlegungen zur Ars medica am Beispiel neuer Entwicklungen in der klinischen Pharmakologie.
in: Kröner et al. ars medica - die verlorene Einheit der Medizin Gustav Fischer Verlag S. 211-224,
1994
Jekat, F.W., H. Sourgens and F.H. Kemper:
Influence of 3, 5-Dimethyl-3-isopropyl-L-thyronine on Thyroid State and Gestational Outcome in the
Wistar Rat.
Arzneim.-Forsch./Drug Res. 43 (II), 1064-1068, 1993
Holbeck, A., T.M. Böckers, W. Wittkowski and H. Sourgens:
Ultrastructure of Fetal Pars-tuberalis-Specific Secretory Cells under the Influence of Propylthiouracile
and Thyroxine.
Acta Anat 147, 64-68, 1993
Winterhoff, H., H.G. Gumbinger and H. Sourgens:
On the antigonadotropic activity of Lithospermum- and Lycopus-species and some of their phenolic
constituents.
Planta Medica 54, 101-106, 1988
Sourgens, H., K. Klages, H.P. Bertram and C. Müller:
Gonadal and thyroid function after experimental lead exposure.
Trace elements in medicine 4, 8-12, 1987
Sourgens H. contributing author to:
International Programme On Chemical Safety, Commission Of The European Communities
Environmental Health Criteria 59, Principles For Evaluating Risks From Chemicals During Infancy
and Early Childhood: The Need For A Special Approach.
Published under the joint sponsorship of the United Nations Environment Programme, the
International Labour Organisation, and the World Health Organization, and on behalf of the
Commission of the European Communities
World Health Orgnization, Geneva, 1986
http://www.inchem.org/documents/ehc/ehc/ehc59.htm
Sourgens, H., A. Frömbling-Borges and F.H. Kemper
Iodine and autoregulation of thyroid gland function: Inhibition of secretion of thyroid hormones in the
rat.
5. Spurenelement-Symposium 1986 M. Anke, W. Baumann, H. Bräunlich, Cr. Bruckner, H. Groppel
(Hrgs). Karl Marx Universität Leipzig, Friedrich Schiller Universität Jena, VEB-Kongress- und
Werbedruck Oberlungwitz, Druckgenehmigung MG 128/73/86
Sourgens, H., H. Winterhoff, H.G. Gumbinger and F.H. Kemper:
Effects of Lithospermum officinale and related plants on hypophyseal and thyroid hormones in the rat.
Int. J. Crude Drug Res. 24, 53 - 63, 1986
Sourgens, H., H. Winterhoff and F.H. Kemper:
Beeinflussung der Schilddrüsenfunktion durch topische Applikation jodhaltiger Desinfektionsmittel
unter besonderer Berücksichtigung von PVP-Jod (Povidon-Jod) - Nutzen und Risiko -.
Münch. Med. Wochenschrift 128, 224 - 226, 1986
Sourgens, H. and F.H. Kemper:
The relative merits of prolactin determinations in toxicological routine studies in the rat.
J. Clin. Chem. Clin. Biochem. 23, 429-431, 1985
Sourgens, H., H. Winterhoff, F.H. Kemper and W. Niemann:
Benefit-risk assessment of povidone-iodine (PVP-J) as hygienic desinfectant in geographic areas of
iodine deficiency.
Thyroid disorders, iodine deficiency and excess. Serono Symposium, Freiburg, April 1984
A. Hall, J. Köbberling (Eds.) Serono Symposia Publications Raven Press,
Vol. 22, New York 1985
Auf’M Kolk, K., J.C. Ingbar, S.M. Amir, H. Winterhoff, H. Sourgens, R.D. Hesch and S.H. Ingbar:
Inhibition by certain plant extracts of the binding and adenylate cyciase stimulatory effect of bovine thyrotropin in human thyroid membranes. Endocrinology 115, 527 - 534, 1984
Sourgens, H., H. Winterhoff, F.H. Kemper, W. Niemann Und B. Högemann:
Pathophysiologische Aspekte der Schilddrüsenfunktion und Ergebnisse humanpharmakologischer
Untersuchungen mit Povidon-Jod.
in: Hierholzer, G. und S. Görtz (Hrsg.): PVP-Jod in der operativen Medizin. 44 - 52, Springer-Verlag,
Berlin - Heidelberg, 1984
Sourgens, H., A.H. Staib, K. Bielicki and V. V. Loewenich:
T4-levels in methylxanthine-treated premature newborns.
Pediatric Pharmacology 3, 267 - 272, 1983
Winterhoff, H., H. Sourgens and F.H. Kemper:
Antihormonal effects of plant extracts. Pharmacodynamic effects of Lithospermum officinale on the
thyroid gland of rats; comparison with the effect of iodide.
Horm. Metabol. Res. 15, 503-507, 1983
Sourgens, H., H. Winterhoff, H.G. Gumbinger and F.H, Kemper:
Antihormonal effects of plant extracts. TSH- and Prolactin-suppressing properties of Lithospermum
officinale and related plants.
Planta Medica 45, 78-86, 1982
Gumbinger, H.G., H. Winterhoff, H. Sourgens, F.H. Kemper and R. Wilde:
Formation of compounds with antigonaciotropic activity from inactive phenolic precursors. Contraception 23, 661-666, 1981
Sourgens, H., H. Winterhoff and F.H. Kemper:
Phytotherapie bei Schilddrüsenerkrankungen.
Phys. Med. u. Reh. 21, 100-102, 1980
Sourgens, H., H. Winterhoff, F.H. Kemper and F. Aenstoots:
The relative merits of polyethylene glycol as a separating agent in the radioimmunoassay of thyroid
hormones.
Clin. Chim. Acta 97, 179-190, 1979
Winterhoff, H. and H. Sourgens:
The predictive value of animal experiences in the detection of side effects of drugs on thyroid function
in men.
Pharmac. Ther. 5, 325-337, 1979
Sourgens, H. and H. Winterhoff:
The value of screening methods for the detection of thyroid "side-effects".
Pharmac. Ther. 5, 319-323, 1979