Publications

Erb-Zohar K, Sourgens H, Breithaupt-Groegler K:

Use of integrated clinical trial protocols - a survey in early medicines development.
Int J Clin Pharmacol Ther. 2018 Feb 16. doi: 10.5414/CP203206. [Epub ahead of print] PubMed PMID: 29451470.

Van Bortel L, Sourgens H, Breithaupt-Grögler K, Caplain H, Donazzolo Y, Klingmann I, Hammond M, Hardman TC, Stringer S, de Hoon J:

EUFEMED London Conference 2017: Exploratory Medicines Development: Innovation and Risk Management.
Front Pharmacol. 2018 Jan 17;8:901. doi: 10.3389/fphar.2017.00901. eCollection 2017. PubMed PMID: 29387006; PubMed Central PMCID: PMC5776107.

Breithaupt-Groegler K, Coch C, Coenen M, Donath F, Erb-Zohar K, Francke K, Goehler K, Iovino M, Kammerer Kp, Mikus G, Rengelshausen J, Sourgens H, Schinzel R, Sudhop T, Wensing G:

Who is a 'healthy subject'? - consensus results on pivotal eligibility criteria for clinical trials.
Eur J Clin Pharmacol. 2017 Jan 7. doi: 10.1007/s00228-016-2189-8.

Sourgens H, Lefrère F:

A systematic review of available clinical evidence - filgrastim compared with lenograstim.
International Journal of Clinical Pharmacology and Therapeutics 2011; 49: 510-518

Sourgens H., M.A. Bertola, J.S.C. Verschoor, M. Kuipers and B. Rayer:

Amoxicillin/clavulanic acid (875/125): bioequivalence of a novel Solutab (R) tablet and rationale for a twice-daily dosing regimen.
International Journal of Clinical Pharmacology and Therapeutics, Vol. 42, No. 2, 165-173, 2004

Sourgens H, J. Schmidt, H. Derendorf:

Comparison of talinolol and atenolol effects on blood pressure in relation to lipid and glucose metabolic parameters. Results from the TALIP study.
Int J Clin Pharmacol Ther. 41, 22-9, 2003

Michael N., H. Sourgens, V. Arolt, A. Erfurth:

Severe tardive dyskinesia in affective disorders: treatment with vitamin E and C.
Neuropsychobiology 46, Suppl 1, 28-30, 2002

Sourgens H., H. Steinbrede, Js. Verschoor, Ma. Bertola, B. Rayer:

Bioequivalence study of a novel Solutab tablet formulation of amoxicillin/clavulanic acid versus the originator film-coated tablet.
Int J Clin Pharmacol Ther. 39, 75-82, 2001
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?
cmd=Retrieve&db=PubMed&list_uids=11270805&
dopt=Citation

Sourgens H.:

Drug Interactions: Gefährdung der Substitution
in: Christian Jellinek / Bernd Westermann / Gabriele U. Bellmann (Hrsg.) Beigebrauch Offene Grenzen der Substitution BELTZ Deutscher Studien Verlag Weinheim 2000

Sourgens H., R. Hoerr, A. Biber, H. Steinbrede, and H. Derendorf:

KA 672-HCl, a neuronal activator against dementia: tolerability, safety, and preliminary pharmacokinetics after single and multiple oral doses in healthy male and female volunteers.
J Clin Pharmacol 38, 373-381, 1998

Sourgens H., H. Derendorf, H. Schifferer:

Pharmacokinetic profile of cefaclor.
Int. J. Clin. Pharmacol. Ther. 35, 374-380, 1997

Merfort F., H. Von Ahlen, Th. Zimmermann, H. Sourgens:

Neue Aspekte in Diagnostik und Therapie der erektilen Dysfunktion.
Münchener Medizinische Wochenschrift 138, 28/504, 1996

Rohatagi S., G. Hochhaus, H. Möllmann, J. Barth, E. Galia, M. Erdmann, H. Sourgens, and H. Derendorf:

Pharmacokinetic and pharmacodynamic evaluation of triamcinolone acetonide after intravenous, oral, and inhaled administration.
J Clin Pharmacol 35, 1187-1193, 1995

Derendorf, H., G. Hochhaus, S. Rohatagi, H. Möllmann, J. Barth, H. Sourgens, H. Erdmann:

Pharmacokinetics of triamcinolone acetonide after intravenous, oral and inhaled administration.
J. Clin. Pharmacol. 35, 302-305, 1995

Barth A., N. Kaiser, U. Loffler, H. Sourgens, and W. Klinger:

Influence of the xanthine derivative denbufylline and the antiinflammatory agent nabumetone on microsomal free-radical production and lipid peroxidation in rat liver.
Experimental and Toxicologic Pathology 46, 483-489, 1994

Sourgens, H.:

Überlegungen zur Ars medica am Beispiel neuer Entwicklungen in der klinischen Pharmakologie.
in: Kröner et al. ars medica - die verlorene Einheit der Medizin Gustav Fischer Verlag S. 211-224, 1994

Jekat, F.W., H. Sourgens and F.H. Kemper:

Influence of 3, 5-Dimethyl-3-isopropyl-L-thyronine on Thyroid State and Gestational Outcome in the Wistar Rat.
Arzneim.-Forsch./Drug Res. 43 (II), 1064-1068, 1993

Holbeck, A., T.M. Böckers, W. Wittkowski and H. Sourgens:

Ultrastructure of Fetal Pars-tuberalis-Specific Secretory Cells under the Influence of Propylthiouracile and Thyroxine.
Acta Anat 147, 64-68, 1993

Winterhoff, H., H.G. Gumbinger and H. Sourgens:

On the antigonadotropic activity of Lithospermum- and Lycopus-species and some of their phenolic constituents.
Planta Medica 54, 101-106, 1988

Sourgens, H., K. Klages, H.P. Bertram and C. Müller:

Gonadal and thyroid function after experimental lead exposure.
Trace elements in medicine 4, 8-12, 1987

Sourgens H. contributing author to:

International Programme On Chemical Safety, Commission Of The European Communities Environmental Health Criteria 59, Principles For Evaluating Risks From Chemicals During Infancy and Early Childhood: The Need For A Special Approach.
Published under the joint sponsorship of the United Nations Environment Programme, the International Labour Organisation, and the World Health Organization, and on behalf of the Commission of the European Communities World Health Orgnization, Geneva, 1986
http://www.inchem.org/documents/ehc/ehc/ehc59.htm

Sourgens, H., A. Frömbling-Borges and F.H. Kemper

Iodine and autoregulation of thyroid gland function: Inhibition of secretion of thyroid hormones in the rat.
5. Spurenelement-Symposium 1986 M. Anke, W. Baumann, H. Bräunlich, Cr. Bruckner, H. Groppel (Hrgs). Karl Marx Universität Leipzig, Friedrich Schiller Universität Jena, VEB-Kongress- und Werbedruck Oberlungwitz, Druckgenehmigung MG 128/73/86

Sourgens, H., H. Winterhoff, H.G. Gumbinger and F.H. Kemper:

Effects of Lithospermum officinale and related plants on hypophyseal and thyroid hormones in the rat.
Int. J. Crude Drug Res. 24, 53 - 63, 1986

Sourgens, H., H. Winterhoff and F.H. Kemper:

Beeinflussung der Schilddrüsenfunktion durch topische Applikation jodhaltiger Desinfektionsmittel unter besonderer Berücksichtigung von PVP-Jod (Povidon-Jod) - Nutzen und Risiko -.
Münch. Med. Wochenschrift 128, 224 - 226, 1986

Sourgens, H. and F.H. Kemper:

The relative merits of prolactin determinations in toxicological routine studies in the rat.
J. Clin. Chem. Clin. Biochem. 23, 429-431, 1985

Sourgens, H., H. Winterhoff, F.H. Kemper and W. Niemann:

Benefit-risk assessment of povidone-iodine (PVP-J) as hygienic desinfectant in geographic areas of iodine deficiency.
Thyroid disorders, iodine deficiency and excess. Serono Symposium, Freiburg, April 1984 A. Hall, J. Köbberling (Eds.) Serono Symposia Publications Raven Press, Vol. 22, New York 1985

Auf’M Kolk, K., J.C. Ingbar, S.M. Amir, H. Winterhoff, H. Sourgens, R.D. Hesch and S.H. Ingbar:

Inhibition by certain plant extracts of the binding and adenylate cyciase stimulatory effect of bovine thyrotropin in human thyroid membranes. Endocrinology 115, 527 - 534, 1984

Sourgens, H., H. Winterhoff, F.H. Kemper, W. Niemann Und B. Högemann:

Pathophysiologische Aspekte der Schilddrüsenfunktion und Ergebnisse humanpharmakologischer Untersuchungen mit Povidon-Jod.
in: Hierholzer, G. und S. Görtz (Hrsg.): PVP-Jod in der operativen Medizin. 44 - 52, Springer-Verlag, Berlin - Heidelberg, 1984

Sourgens, H., A.H. Staib, K. Bielicki and V. V. Loewenich:

T4-levels in methylxanthine-treated premature newborns.
Pediatric Pharmacology 3, 267 - 272, 1983

Winterhoff, H., H. Sourgens and F.H. Kemper:

Antihormonal effects of plant extracts. Pharmacodynamic effects of Lithospermum officinale on the thyroid gland of rats; comparison with the effect of iodide.
Horm. Metabol. Res. 15, 503-507, 1983

Sourgens, H., H. Winterhoff, H.G. Gumbinger and F.H, Kemper:

Antihormonal effects of plant extracts. TSH- and Prolactin-suppressing properties of Lithospermum officinale and related plants.
Planta Medica 45, 78-86, 1982

Gumbinger, H.G., H. Winterhoff, H. Sourgens, F.H. Kemper and R. Wilde:

Formation of compounds with antigonaciotropic activity from inactive phenolic precursors. Contraception 23, 661-666, 1981

Sourgens, H., H. Winterhoff and F.H. Kemper:

Phytotherapie bei Schilddrüsenerkrankungen.
Phys. Med. u. Reh. 21, 100-102, 1980

Sourgens, H., H. Winterhoff, F.H. Kemper and F. Aenstoots:

The relative merits of polyethylene glycol as a separating agent in the radioimmunoassay of thyroid hormones.
Clin. Chim. Acta 97, 179-190, 1979

Winterhoff, H. and H. Sourgens:

The predictive value of animal experiences in the detection of side effects of drugs on thyroid function in men.
Pharmac. Ther. 5, 325-337, 1979

Sourgens, H. and H. Winterhoff:

The value of screening methods for the detection of thyroid "side-effects".
Pharmac. Ther. 5, 319-323, 1979