Vorträge und Poster

Sourgens H:

Solved problems and unsolved challenges in applied human pharmacology
AGAH Annual Meeting 2010, Hamburg, February 21 - 23

Sourgens H., Vetter A., Thyroff-Friesinger U., Sörgel F., Kinzig M., Vens-Capell B., Rehak E.:

Clinical Pharmacology of HX575, the first approved biosimilar epoetin alfa in Europe.
IXth World Conference on Clinical Pharmacology and Therapeutics, Quebec City, Canada, 27. July - 1. August, 2008. Abstract T2TH042

Sourgens H.:

Clinical development programmes for biosimilars.
Plenary lecture, AGAH Annual Meeting 2008, Weimar, April 18 and 19, 2008

Sourgens H.:

Drug Interactions: Gefährdung der Substitution
Plenary lecture, Symposium Beigebrauch Offene Grenzen der Substitution, Berlin, 19. and 20. May 2000

Sourgens H.:

Stellenwert der Toxikokinetik im "Risk-Benefit Assessment"
Phytopharmakaforschung 2000 Forschungsergebnisse zu Qualität, Wirksamkeit und Unbedenklichkeit.
Gemeinsames Symposium der Gesellschaft für Phytotherapie e.V. und der Gesellschaft für Arzneipflanzenforschung e.V. Bonn 27.-28.11.1998
http://www.phytotherapy.org/kongress1998.htm

Sourgens H.:

European studies in women's health.
Plenary lecture, 57th International Congress of FIP, World Congress of Pharmacy and Pharmaceutical
Sciences ‘97, Vancouver Canada, 31st August - 5th September 1997

Zussman Bd, Cc. Davie, Se Fowles, R. Kumar, U. Lang, M. Wargenau, H. Sourgens:

Sertraline, like other SSRIs, is a significant inhibitor of desipramine metabolism in vivo.
Br J Clin Pharmacol 39, 550P-551P, 1995

Siederer S., M.A. Pue, A.J. Fairless, R.S. Hucker, H. Collie, H. Sourgens:

High Bioavailability and Rapid Distribution of Penciclovir Following an Oral Dose of Famciclovir.
Antiviral Research 26, A339-A339, 1995

Sourgens H.:

Schwangerschaft im Rahmen klinischer Studien, eine medizinische Indikation zum Schwangerschaftsabbruch?
Vortrag, Herbsttagung der AGAH, Göttingen 1994

Sourgens H.:

Entwicklung gastrointestinaler Arzneimittel.
Vortrag, Jahrestagung der AGAH Köln 1993

Thomsen T., A. Allen, H. Sourgens, Fe. Köster, W. Greb, M. Brett, H. Collie, J. Kurth:

Pharmacokinetics of granisetron (BRL 43694A) in man before and after enzyme induction by phenobarbital.
5th World Conference on Clinical Pharmacology and Therapeutics, Yokohama, Japan, 26.-31.07.1992. Abstract P-405-01

Glöckner R., Jähne F., Schwarz S., Sourgens H., Böckers T.:

Verlängerte Tragzeit bei Ratten Uje: WIST durch Störungen während der Trächtigkeit, Assoziation mit verzögerter Fetalentwicklung.
Vortrag zum 6. Symposium der AG Teratologie 27.-30.9.1989, Greifswald

Glöckner R., Schwarz S., Jähne F., Sourgens H., Böckers T.:

Influence of treatment with lithium during pregnancy on reproductive performance of Fl-female rats.
Sixth International Symposium on Molybdenum, Vanadium and other Trace Elements, Jena, July 1989

Sourgens H., Damman E., Schepers G.:

Jodine deficiency and substitution - effects on fetal and postnatal thyroid function in the rat.
Sixth International Symposium on Molybdenum, Vanadium and other Trace Elements, Jena, July 1989

Sourgens H., Böckers T., Pera F. and Wittkowski W.:

Perinatal development of pituitary hormone production in relation to thyroid gland function.
VII. Symposium on Developmental Pharmacology, Reinhardsbrunn Castle, May 2-5 1989

Greb W.H., Buscher G., Köster F.E., Nix N., Sourgens H., Thomsen T.:

A study to test the effect of diproteverine on the thyroid in normal volunteers.
Poster presentation, The British Toxicology Society and the Society for Drug Research, Churchill College, Cambridge, 12-14 April 1989

Sourgens H.:

Predictivity of animal models for endocrine toxicity.
Plenary lecture, The British Toxicology Society and the Society for Drug Research, Churchill College, Cambridge, 12-14 April 1989

Sourgens H., Böckers T., Pera F. and Wittkowski W.:

Adverse effects of 7 Dimethyl-6-Deoxytetracycline (Minocycline) on the thyroid gland of the rat.
Naunyn-Schmiedeberg's Arch. Pharmacol., suppl. to Vol. 339, R 76, 1989

Greb W.H., Buscher G., Köster F.E., Nix N., Sourgens H., Thomsen T.:

A study to test the effect of diproteverine on the thyroid in normal volunteers.
Poster presentation, The British Toxicology Society and the Society for Drug Research, Churchill College, Cambridge, 12-14 April 1989

Sourgens H.:

Predictivity of animal models for endocrine toxicity.
Plenary lecture, The British Toxicology Society and the Society for Drug Research, Churchill College, Cambridge, 12-14 April 1989

Steinacker A., Sourgens H. and Wittkowski W.:

Adverse effects of 7 Dimethyl-6-Deoxytetracycline (Minocycline) on the thyroid gland of the rat.
Naunyn-Schmiedeberg's Arch. Pharmacol., suppl. to Vol. 339, R 76, 1989

Sourgens H., Böckers T.M., Pera F. and Wittkowski W.:

Perinatal development of pituitary hormone production; morphological and functional aspects and the role of thyroid function.
Acta endocrinologica suppl. 1 p 212, 1989

Böckers T.M., Pera F., Sourgens H., Jekat A., Wittkowski W.:

Changes in the TSH-like immunoreactivity of the fetal pars tuberalis after maternal administration of propyithiouracil (PTU), thyroxine (T4), caffeine and serotonin precursor tryptophan.
Acta endocrinologica suppl. 1 p 216, 1989

Sourgens H.:

Endokrine Regulationen - Modulation durch Phytopharmaka.
2. Tagung der Gesellschaft für Phytotherapie, Münster, 20.- 22.10.1988

Frömbling-Borges A., Sourgens H. and Kemper F.H.:

Hemmung der Schilddrüsensekretion durch Pflanzeninhaltsstoffe; Untersuchung zur Struktur- Wirkungs-Beziehung.
2. Tagung der Gesellschaft für Phytotherapie, Münster, 20.- 22.10.1988

Bickhoff P., Sourgens H. and Kemper F.H.:

Beeinflussung der antihormonalen Wirksamkeit von Lycopus europaeus durch Neurotransmitter.
2. Tagung der Gesellschaft für Phytotherapie, Münster, 20.- 22.10.1988

Jekat, F.W., A. Jekat, H. Sourgens and F.H. Kemper:

Effects of maternal tryptophan and caffeine exposure on fetal development in relation to thyroid activity in the rat.
European Society for Developmental Pharmacology, 1st Congress, April 21 - 23, Les Diablerets, 1988

Sourgens H.:

Pharmakodynamik des Jod unter besonderer Berücksichtigung der Strumatherapie.
Jena, März 1988 - Vortrag vor der Arbeits- und Forschungsgemeinschaft Perinatologie an der Univ. Kinderklinik.

Jekat, F.W., A. Jekat, H. Sourgens and F.H. Kemper:

Perinatal effects of maternal caffeine exposure in relation to thyroid activity in the rat.
Naunyn-Schmiedeberg's Arch. Pharmacol., Suppl. to Vol. 337, R. 82, 1988

Damman, E., H. Sourgens and F.H. Kemper:

Fetal thyroid gland morphology in iodine deficiency and after treatment with thyroid hormone agonists.
32. Symposion Deutsche Gesellschaft für Endokrinologie, Hamburg, 1988

Sourgens, H., E. Lerp and F.H. Kemper:

The impact of the hair dye component 2,4-diaminoanisole on thyroid gland functions and its regulation.
Eurotox, Straßburg, 1987

Kemper, F.H., H. Sourgens and G. Uthe-Kassenbrock:

Adverse effects of UV-filters on the thyroid gland.
Eurotox, Straßburg, 1987

Kemper, F.H., H. Sourgens and E. Lerp:

Black thyroid syndrome due to the hair dye component 2,4-diaminoanisole and its relation to hormonal changes in the rat.
European Thyroid Association, Lausanne, 1987

Sourgens, H., B. Herold and F.H. Kemper:

Role of Iodide and Thyroid Hormones in fetal lung maturation in the rat.
First European Congress of Endocrinology, Copenhagen, 1987

Klages, K., H. Sourgens, H.P. Bertram, C. Müller and F.H. Kemper:

Lead exposure and endocrine functions: Impact on the hypophyseal-gonadal axis and the pituitarythyroid system.
Acta endocrin., Suppl. 283, Vol. 114, 17 - 18, 1987

Sourgens, H., Y. Welim, I. Hentze and F.H. Kemper:

TSH-stimulated secretion and its relation to thyroid function in the rat.
Acta endocrin., Suppl. 283, Vol. 114, 82 - 83, 1987

Sourgens H.:

Beeinflussung der sekretorischen Aktivität der Schilddrüse. Lungenreifung und Schilddrüsenfunktion.
Jena, Oktober 1986 - Vortrag vor der Medizinischen Fakultät und der Arbeits- und Forschungsgemeinschaft Perinatologie

Bickhoff, P., H. Sourgens and F.H. Kemper:

Interference of cinnamic acid derivatives and Lycopus europ. with the neuroendocrine control of prolactin and TSH in the rat.
Joint Meeting of the German Pharmacological Society and the Swiss Society for Pharmacology and Toxicology, Mannheim, September 1986
Naunyn-Schmiedeberg's Arch. Pharmacol., Suppl. to Vol. 334, R 41, 1986

Hentze, I., H. Sourgens and F.H. Kemper:

A Pharmacological approach to the inhibition of the thyroidal secretion.
Joint Meeting of the German Pharmacological Society and the Swiss Society for Pharmacology and Toxicology, Mannheim, September 1986
Naunyn-Schmiedeberg's Arch. Pharmacol., Suppl. to Vol. 334, R 40, 1986

Sourgens H., Y. Welim, H. Winterhoff and F.H. Kemper:

Physiological and pharmacological regulation of thyroidal secretion in the rat.
Joint Meeting of the German Pharmacological Society and the Swiss Society for Pharmacology and Toxicology, Mannheim, September 1986
Naunyn-Schmiedeberg's Arch. Pharmacol., Suppl. to Vol. 334, R 40, 1986

Bergmann M., W. Wittkowski, K. Hoffmann, H. Sourgens and M. Volkenandt:

Influence of photoperiod on morphology and immunoreactivity of hypophysial pars tuberalis of the Djungarian Hamster, Phodopus Sungorus.
Anatomie Kongress, Gießen 1986

Sourgens H.:

Iodine and autoregulation of thyroid gland function: Inhibition of secretion and excess secretion of thyroid hormones in rat and man.
5th International Symposium on Iodine and Other Trace Elements Jena, July 1986

Sourgens H., A. Borges and F.H. Kemper:

Inhibition of endocytosis in highly stimulated thyroid follicles in vivo.
15. Annual Meeting of the European Thyroid Association, Stockholm, June 1986
Annales d'endocrinologie Vol.47, 111 A

Sourgens H.:

Blei und Endokrinium
V. Symposium über Spurenelemente Münster, April 1986

Sourgens H. and F.H. Kemper:

Morphologic effects of the hair-dye component 2,4 diaminoanisole on the rat thyroid and its relation to hormonal changes.
30. Symposium Deutsche Gesellschaft für Endokrinologie München, März 1986
Acta Endocrinologica, Vol. 111, Suppl. 274, 1986

Herold B., H. Sourgens and F.H. Kemper:

Fetal lung maturity and thyroid hormone status.
Joint Meeting of the Belgian, Dutch, and German Pharmacological and Toxicological Societies Aachen, September 1985
Naunyn-Schmiedeberg's Arch. Pharmacol., Suppl. to Vol. 330, R19, 1985

Sourgens H., M.L. Weischer and F.H. Kemper:

Effects of the hair-dye component 2,4-diaminoanisole on the endocrine system and behavior.
Joint Meeting of the Belgian, Dutch, and German Pharmacological and Toxicological Societies Aachen, September 1985
Naunyn-Schmiedeberg's Arch. Pharmacol., Suppl. to Vol. 330, R19, 1985

Sourgens, H., B. Herold and F.H. Kemper:

Effects of maternal medication (3'Isopropyl-3,5-dimethyl-L-thyronine (DIMIT), Dexamethasone, 3(4' CH3 Benzyliden)-campher and Iodide on fetal thyroid hormone status and fetotoxicity in the rat.
Verne Colloque International de Pharmacologie du Developpement Lyon, Juin 1985

Sourgens H. and F.H. Kemper:

Adverse effects of the hair-dye component 2,4-diaminoanisole on the thyroid gland of the rat.
26. Frühjahrstagung der Deutschen Pharmakologischen Gesellschaft, Mainz, März 1985
Naunyn-Schmiedeberg's Arch. Pharmacol., Suppl. to Vol. 329, R24, 1985

Sourgens H. and F.H. Kemper:

The relative merits of prolactin-determinations in toxicological routine studies in the rat.
Kleinkonferenz "Prolactin im Tierversuch" der Arbeitsgruppe "Klinische Chemie bei Laboratoriumstieren" der Deutschen Gesellschaft für Klinische Chemie, Rödermark, November 1984
J. Clin. Chem. Clin. Biochem. 1984

Kolodziej, Ch., H. Sourgens, H.G. Gumbinger Und F.H. Kemper:

Beeinflussung des Hypophysenvorderlappenhormons Prolaktin durch Lycopus europaeus (Lamiaceae).
32. Vortragstagung der Arzneipflanzenforschung, Antwerpen, Juli 1984
Farmaceutisch Tijdschrift voor Belgie 61, 312-313, 1984

Frömbling, A., H. Sourgens and F.H. Kemper:

In-Vivo-Testung von Lycopus europaeus und verschiedenen Zimtsäure-Derivaten hinsichtlich eines direkten Einflusses auf die sekretorische Aktivität der Schilddrüse.
32. Vortragstagung der Arzneipflanzenforschung, Antwerpen, Juli 1984
Farmaceutisch Tijdschrift voor Belgie 61, 253, 1984

Sourgens H., A.H. Staib, F.H. Kemper, V. V. Loewenich, M. Bielicki and M. Müller:

T4- and TSH-levels in methylxanthine - exposed premature and healthy newborns.
Symposium "Plasmakonzentration - Wirkungsbeziehung von Pharmaka", Stuttgart, Mai 1984

Sourgens H., H. Winterhoff and F.H. Kemper:

Benefit-risk-assessment of povidone-iodine (PVP-J) as hygienic desinfectant in geographic areas of iodine deficiency.
Thyroid disorders, iodine deficiency and excess, Serono Symposium, Freiburg, April 1984

Sourgens H.:

T3-Hyperthyroidism and goiter in the rat induced by medicinal plant extracts.
25. Frühjahrstagung der Deutschen Pharmakologischen Gesellschaft, Mainz, März 1984
Naunyn-Schmiedeberg's Arch. Pharmacol., Suppl. to Vol. 325, R29, 1984

Staib, A.H.,, H. Sourgens, V. V. Loewenich, M. Bielicki and M. Müller:

Do methylxanthines influence T4- and TSH-levels in premature infants as compared to healthy newborn and asthmatics?
Joint Meeting of the French and German Pharmacological and Toxicological Societies, Freiburg i.Br., September 1983
Naunyn-Schmiedeberg's Arch. Pharmacol., Suppl. to Vol. 324, R78, 1983

Wylde, R., A. Sosa, F. Winternitz, H.G. Gumbinger, H. Winterhoff, H. Sourgens and F.H. Kemper:

Investigations on the structure-function-relationship and the antigonadotropic activity of phenolic compounds.
Joint Meeting of the French and German Pharmacological and Toxicological Societies, Freiburg i.Br., September 1983
Naunyn-Schmiedeberg's Arch. Pharmacol., Suppl. to Vol. 324, R58, 1983

Sourgens, H., Ch. Kolodziej and F.H. Kemper:

Effects of Lycopus europaeus extracts on the serotoninergic transmission of TSH- and Prolactin release in the rat.
Joint Meeting of the French and German Pharmacological and Toxicological Societies, Freiburg i.Br., September 1983
Naunyn-Schmiedeberg's Arch. Pharmacol., Suppl. to Vol. 324, R56, 1983

Frömbling, A., H. Sourgens and F.H. Kemper:

The thyroidal secretion inhibiting effect of thyroid hormone metabolites, plant constituants and Lithium chloride can be abolished by subsequent TSH-application.
Joint Meeting of the French and German Pharmacological and Toxicological Societies, Freiburg i.Br., September 1983
Naunyn-Schmiedeberg's Arch. Pharmacol., Suppl. to Vol. 324, R56, 1983

Sourgens H., A.H. Staib, V. V. Loewenich and N. Bielicki:

T4-levels in methylxanthine treated premature newborns.
International Symposium on Pediatric Clinical Pharmacology, Düsseldorf, Mai 1983

Uthe-Kassenbrock, G., H. Sourgens and F.H. Kemper:

Observation on the interrelation between thyroid and thymus function in the toxicological screening process.
Deutsche Pharmakologische Gesellschaft, Deutsche Physiologische Gesellschaft, Joint Spring Meeting, Mainz, März 1983
Naunyn-Schmiedeberg's Arch. Pharmacol., Suppl. to Vol. 322, R59, 1983

Auf'm Kolk, M., J. Ingbar, S. Amir, H. Winterhoff, H. Sourgens and S.H. Ingbar:

The effects of Lycopus virginicus and other plant extracts on the binding of TSH to human thyroid plasma membranes and on adenylate cyclase activation.
26. Symposium Deutsche Gesellschaft für Endokrinologie, Salzburg, Februar 1982
Acta Endocrinol. (Kbh.) 99, Suppl. 246, 1982

Sourgens, H., F.H. Kemper, D. Winterhoff and W. Niemann:

PVP-iodine containing antiseptics interfere with thyroid hormone economy after cutaneous application.
23. Frühjahrstagung der Deutschen Pharmakologischen Gesellschaft, Mainz, März 1982
Naunyn-Schmiedeberg's Arch. Pharmacol., Suppl. to Vol. 319, R88, 1982

Ingbar, J., M. Auf'm Kolk, S.Amir, H. Winterhoff, H. Sourgens, R.D. Hesch and S.H. Ingbar:

Inhibition of the binding of TSH and Graves'-IgG to human thyroid membranes by certain plant extracts.
American Thyroid Association, 57th Meeting, Minneapolis, September 1981
Endocrinology, Suppl. to Vol. 109, T 17, 1981

Köhrle, J., M. Auf'm Kolk, R.D. Hesch, H. Winterhoff, H. Sourgens and H.G. Gumbinger:

Plant inhibitors of iodothyronine deiodinases.
14th FEBS Meeting, Edinburgh, April 1981
Biochem. Society Transactions 9, 3248, 1981

Köhrle, J., M. Auf'm Kolk, H. Winterhoff, H. Sourgens and H.G. Gumbinger:

lodothyronine deiodinases: Inhibition by plant extracts.
25. Symposium Deutsche Gesellschaft für Endokrinologie, Berlin, März 1981
Acta Endocrinol. (Kbh.) 96, Suppl. 240, 1981

Sourgens, H. and F.H. Kemper:

Antithyroidal properties of Lithospermum officinale and related plants.
25. Symposium Deutsche Gesellschaft für Endokrinologie, Berlin, März 1981 Acta Endocrinol. (Kbh.) 96, Suppl. 240, 1981

Sourgens, H., Ch. Kolodziej and F.H. Kemper:

Differences in the pharmacodynamic effects of freeze dried plant extracts against hypophyseal and thyroid hormones in the rat.
22. Frühjahrstagung der Deutschen Pharmakologischen Gesellschaft, Mainz, März, 1981
Naunyn-Schmiedeberg's Arch. Pharmacol., Suppl. to Vol. 316, R49, 1981

Winterhoff, H., H.G. Gumbinger, H. Sourgens Und F.H. Kemper:

Zur Isolierung antigonadotrop wirksamer Inhaltsstoffe aus verschiedenen Arten der Gattungen Lithospermum und Lycopus.
International Research Congress on Natural Products as Medical Agents, Straßburg, Juli 1980
Planta Medica 39, 245, 1980

Sourgens, H., H. Winterhoff, H.G. Gumbinger and F.H. Kemper:

Wirkprofile verschiedener Boraginaceen und Lamiaceen im Hypophysenvorderlappen- Schilddrüsensystem der Ratte.
International Research Congress on Natural Products as Medical Agents, Straßburg, Juli 1980
Planta Medica 39, 245-246, 1980

Sourgens, H., H. Winterhoff, H.G. Gumbinger, R. Mendes and F.H. Kemper:

Antihormonal effects of plant extracts on hypophyseal hormones in the rat.
24. Symposion Deutsche Gesellschaft für Endokrinologie, Berlin, Juni 1980
Acta Endocrinol. (Kbh.) 94, Suppl. 234, 1980

Mendes, R., H. Sourgens, and F.H. Kemper:

Interaction of different plant ingredients with hypothalamic-hypophyseal hormones in the rat.
21. Frühjahrstagung der Deutschen Pharmakologischen Gesellschaft, Mainz, März 1980
Naunyn-Schmiedeberg's Arch. Pharmacol., Suppl. to Vol. 311, R53, 1980

Winterhoff, H., H. Sourgens, H.G. Gumbinger and F.H. Kemper:

Effect of acute and chronic application of antihormonal plant extracts.
Acta-Endocrinologica Kongreß, München, Juni 1979
Acta Endocrinol. (Kbh.) 91, Suppl. 225, 1979

SOURGENS, H.:

Further investigations on the mechanism of action of freeze dried extracts of Lithospermum officinale L.
20. Frühjahrstagung der Deutschen Pharmakologischen Gesellschaft, Mainz, März 1979
Naunyn-Schmiedeberg's Arch. Pharmacol., Suppl. to Vol. 3o7, R51, 1979

Winterhoff, H., H. Sourgens, K.D. Döhler and F.H. Kemper:

Influence of plant extracts on pituitary-thyroid interplay and peripheral thyroid hormone metabolism.
9. Jahrestreffen der European Thyroid Association, Berlin, September 1978 Annales d'endocrinologie 39, 14 A, 1978

Kemper, F., H. Winterhoff, H. Sourgens Und K. Niehaus:

Zur antigonadotropen und antithyreotropen Wirkung von Pflanzenextrakten.
International meeting on medical plant research, Münster, Mai 1978 Planta Medica 33, 311, 1978

H. Winterhoff, H. Sourgens, F. Kemper and F. Aenstoots:

Pharmakodynamische Wirkungen von Lithospermum officinale auf den Schilddrüsenstoffwechsel bei Ratten.
19. Frühjahrstagung der Deutschen Pharmakologischen Gesellschaft, Mainz, März 1978
Naunyn-Schmiedeberg's Arch. Pharmacol., Suppl. to Vol. 302, R45, 1978

H. Sourgens and F. Aenstoots:

Influence of different buffer systems on the accuracy of thyroid hormone determination.
18. Frühjahrstagung der Deutschen Pharmakologischen Gesellschaft, Mainz, März 1977
Naunyn-Schmiedeberg's Arch. Pharmacol., Suppl. to Vol. 297, R42, 1977

H. Winterhoff and H. Sourgens:

The predictive value of animal experiences in the detection of side effects of drugs on thyroid function in men.
International workshop on pharmacological methods in preclinical safety evaluation of new drugs, Zürich, Oktober 1977

H. Sourgens and H. Winterhoff:

The value of screening methods for the detection of thyroid "side-effects".
International workshop on pharmacological methods in preclinical safety evaluation of new drugs, Zürich, Oktober 1977

H. Sourgens, F. Aenstoots, H. Winterhoff and F.H. Kemper:

On the radioimmunological determination of thyroid hormones.
17. Frühjahrstagung der Deutschen Pharmakologischen Gesellschaft, Mainz, März 1976
Naunyn-Schmiedeberg's Arch. Pharmacol., Suppl. to Vol. 293, R38, 1976